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LINKS TO INTERACTIVE 3-D STRUCTURES1 of IMMUNE EFFECTOR MOLECULES |
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ANTIBODY DOMAIN STRUCTURES |
MHC
CLASS II STRUCTURES: |
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Human IgG1 Domain Animations (JMOL) |
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Overview: HLA-DR1 + Flu virus hemagglutinin peptide (CHIME) |
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Overview: Human IgG1 (CHIME) |
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Animation: HLA-DR1 + (Ala)13 (CHIME) |
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VL-VH Domain Interactions (CHIME) |
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HLA-DR1 Complex with Staph Enterotoxin B Super Antigen (CHIME) |
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CL-CH1 Domain Interactions + Interchain H-L Disulfide (CHIME) |
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HL-DR3 Complex with CLIP (Class II Associated Invariant Chain Peptide) (CHIME) |
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Hinge Region + Interchain H-H Disulfides (CHIME) |
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HL-DR1 Complex with CLIP (CHIME) |
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CH2-CH2 Domains + Carbohydrate Interactions (CHIME) |
T CELL RECEPTOR AND CO-RECEPTOR MOLECULES |
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CH3-CH3 Domain Interactions (CHIME) |
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TCR Overview (CHIME) |
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ANTIBODY-ANTIGEN INTERACTIONS |
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TCR Alpha/Beta Dimer (CHIME) |
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Monoclonal Fab/Hen Egg-White Lysozyme Complex (JMOL) |
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TCR Interdomain Interactions (CHIME) |
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Two Monoclonal Fab/Hen Egg-White Lysozyme Complexes (JMOL) |
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TCR Hypervariable Regions (CHIME) |
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Catalytic Antibody: Mouse Monoclonal Abzyme + Hapten (CHIME) |
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TCR Antigen Binding Sites (CHIME) |
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MHC
CLASS I STRUCTURES: HUMAN (HLA-A,B,C) AND MOUSE (H-2K,D,L) |
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TCR-Antigen-Class I Complex (CHIME) | |
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Overview: HLA-Aw68.1 (CHIME) | TARGETED PATHOGEN STRUCTURES | |
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Animation: H-2Kb + SEV-9 Peptide (CHIME) |
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Dual Peptide Binding to H-2Kb: SEV-9 and OVA-8 Peptides (CHIME) |
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Human Immunodeficiency Virus (HIV): Protease + Inhibitor (CHIME) |
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MECHANISMS OF ANTIBODY AND T-CELL RECEPTOR DIVERSIFICATION | ||
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Antigen-Class I-CD8 Complex: HLA-A2 + Ag + CD8 Dimer (CHIME) |
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V-J Joining: Junctional Diversification by Alternate DNA Joining (CHIME) |
| CYTOKINE AND CYTOKINE RECEPTOR STRUCTURES | |||
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Lymphotoxin/TNF Receptor Complex (CHIME) | ||
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| LINKS TO OTHER INSTRUCTIONAL WEBPAGES | |||
| Adaptive and Innate Immune Cells | ANTIBODY-ANTIGEN INTERACTIONS | ||
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Ion Electrophoresis (FLASH ANIMATION) |
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FACs Analysis of Antibody-Antigen Interactions (FLASH ANIMATION) |
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1In order to view the structural images embedded in the various webpages found on this site, your browser needs to have the following two browser plug-ins active: The Jmol plug-in, which requires installation of the Standard Java Platform, is designed to function with any browser in either a Windows or a Mac environment. However, the MDL Chime plug-in is currently designed only for Windows versions of Internet Explorer but it will function with the FireFox browser if one copies the plug-in files found in the plug-in folder of Internet Explorer to the plug-in folder of the FireFox browser. |
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